Comics Continuum have posted a video with IDW's Tom Waltz in which he briefly discusses Infestation 2, which is planned to start in January 2012. As previously reported, this time there will be more direct crossovers, plus there will be more franchises involved, as well as a new bad guy.
According to Newsarama's coverage of IDW "Greatest Panel Ever" at the San Diego Comic Con, IDW showed artwork from the series, featuring Transformers and G.I. Joe, plus new additions Danger Girl and Teenage Mutant Hero Turtles. This report also gives a title of "Infes2ation".
Comics Alliance meanwhile, reports the sequel series will have all the original Infestation series (Covert Vampiric Operations, Star Trek, Ghostbusters, G.I. Joe and Transformers). Plus the aforementioned new licenses Danger Girl and Teenage Mutant Hero Turtles, aas well as Weekly World News and Groom Lake - The latter of which has already been tied into the Infestation: Outbreak sequel, which started this summer.